Publications
2025
Fernández-Pascual, M.; Brethomé, A. V.; Sidera, M.; Fletcher, S. P. Divergent contiguous stereocenters via asymmetric conjugate additions to cycloalkenyl ketones. Chem Catalysis 2025, 5 (10). DOI: 10.1016/j.checat.2025.101486 (acccessed 2025/10/20).
Liu, K.; Egea-Arrebola, D.; Ardkhean, R.; Cunningham, L.; Christensen, K.; Paton, R.; Fletcher, S. Ligand-enabled override of the memory effect in Rh-catalyzed asymmetric Suzuki reactions. Chem 2025, 11 (9), 11. DOI: 10.1016/j.chempr.2025.102550.
2024
Zhang, Z.; Howlett, M.; Silvester, E.; Kukura, P.; Fletcher, S. A Chemical Reaction Network Drives Complex Population Dynamics in Oscillating Self-Reproducing Vesicles. J. Am. Chem. Soc. 2024, 146 (27), 18262–18269. DOI: 10.1021/jacs.4c00860.
Webster, S.; Cunningham, L.; Fletcher, S. Rhodium-Catalyzed Asymmetric Suzuki and Related Cross-Coupling Reactions. Aldrichimica Acta 2024, 57 (1), 32.
Webster, S.; Balázs, L.; Goetzke, F.; Stojalnikova, V.; Liu, K.; Christensen, K.; Mackenzie, H.; Fletcher, S. Rh(I)-Catalyzed Regio- and Enantioselective Ring Opening of Vinyl Cyclopropanes. J. Am. Chem. Soc. 2024, 146 (35), 24708–24715. DOI: 10.1021/jacs.4c09490.
Stojalnikova, V.; Webster, S.; Liu, K.; Fletcher, S. Chelation enables selectivity control in enantioconvergent Suzuki-Miyaura cross-couplings on acyclic allylic systems. Nat. Chem. 2024, 16 (5), 10. DOI: 10.1038/s41557-023-01430-8.
Howlett, M.; Engwerda, A.; Fletcher, S. Information transduction via fuel-controlled chemical waves. Chem 2024, 10 (9), 12. DOI: 10.1016/j.chempr.2024.05.010.
2023
Mishra, S.; Karabiyikoglu, S.; Fletcher, S. Catalytic Enantioselective Synthesis of 3-Piperidines from Arylboronic Acids and Pyridine. J. Am. Chem. Soc. 2023, 145 (26), 14221–14226. DOI: 10.1021/jacs.3c05044.
Howlett, M.; Fletcher, S. From autocatalysis to survival of the fittest in self-reproducing lipid systems. Nat. Rev. Chem. 2023, 7 (10), 673–691, Review. DOI: 10.1038/s41570-023-00524-8.
Egea-Arrebola, D.; Goetzke, F.; Fletcher, S. Rhodium-Catalyzed Asymmetric Arylation of Cyclobutenone Ketals. Angew. Chem.-Int. Edit. 2023, 62 (13), 5. DOI: 10.1002/anie.202217381.
2022
Zhang, Y.; Goetzke, F.; Christensen, K.; Fletcher, S. Asymmetric Synthesis of Nortropanes via Rh-Catalyzed Allylic Arylation. ACS Catal. 2022, 12 (15), 8995–9002. DOI: 10.1021/acscatal.2c02259.
Mishra, S.; Modicom, F.; Dean, C.; Fletcher, S. Catalytic asymmetric synthesis of carbocyclic C-nucleosides. Comm. Chem. 2022, 5 (1), 9. DOI: 10.1038/s42004-022-00773-6.
Howlett, M.; Engwerda, A.; Scanes, R.; Fletcher, S. An autonomously oscillating supramolecular self-replicator. Nat. Chem. 2022, 14 (7), 805–+. DOI: 10.1038/s41557-022-00949-6.
Goetzke, F.; Sidera, M.; Fletcher, S. Catalytic asymmetric hydrometallation of cyclobutenes with salicylaldehydes (Jan, 10.1039/d1sc06035j, 2022). Chem. Sci. 2022, 13 (4), 1177–1177, Correction. DOI: 10.1039/d1sc90265b.
Cunningham, L.; Portela, M.; Fletcher, S. Scale-Up of a Rh-Catalyzed Asymmetric sp3-sp2 Suzuki-Miyaura- Type Reaction. Org. Process Res. Dev. 2022, 26 (11), 3153–3160. DOI: 10.1021/acs.oprd.2c00268.
Cunningham, L.; Mishra, S.; Matthews, L.; Fletcher, S. A General Catalyst Controlled Route to Prostaglandin F2α. Org. Lett. 2022, 24 (48), 8886–8889. DOI: 10.1021/acs.orglett.2c03718.
2021
van Dijk, L.; Fletcher, S. Y Rh-catalyzed asymmetric Suzuki-Miyaura cross-coupling. Trends Chem. 2021, 3 (9), 795–796, Editorial Material. DOI: 10.1016/j.trechm.2021.05.007.
van Dijk, L.; Ardkhean, R.; Sidera, M.; Karabiyikoglu, S.; Sari, Ö.; Claridge, T.; Lloyd-Jones, G.; Paton, R.; Fletcher, S. Mechanistic investigation of Rh(i)-catalysed asymmetric Suzuki-Miyaura coupling with racemic allyl halides. Nat. Catal. 2021, 4 (4), 284–292. DOI: 10.1038/s41929-021-00589-y.
Howlett, M.; Scanes, R.; Fletcher, S. Selection between Competing Self-Reproducing Lipids: Succession and Dynamic Activation. JACS Au 2021, 1 (9), 1355–1361. DOI: 10.1021/jacsau.1c00138.
Goetzke, F.; Sidera, M.; Fletcher, S. Catalytic asymmetric hydrometallation of cyclobutenes with salicylaldehydes. Chem. Sci. 2021, 13 (1), 236–240. DOI: 10.1039/d1sc06035j.
Goetzke, F.; Hell, A.; van Dijk, L.; Fletcher, S. A catalytic asymmetric cross-coupling approach to the synthesis of cyclobutanes. Nat. Chem. 2021, 13 (9), 880–+. DOI: 10.1038/s41557-021-00725-y.
Goetzke, F.; Fletcher, S. Additions to Racemates: A Strategy for Developing Asymmetric Cross-Coupling Reactions. Synlett 2021, 32 (18), 1816–1825. DOI: 10.1055/s-0040-1706033.
Babu, D.; Scanes, R.; Plamont, R.; Ryabchun, A.; Lancia, F.; Kudernac, T.; Fletcher, S.; Katsonis, N. Acceleration of lipid reproduction by emergence of microscopic motion. Nat. Commun. 2021, 12 (1), 7. DOI: 10.1038/s41467-021-23022-1.
2020
Wang, J.; Fletcher, S. Synthesis of the Taxol Core via Catalytic Asymmetric 1,4-Addition of an Alkylzirconium Nucleophile. Org. Lett. 2020, 22 (11), 4103–4106. DOI: 10.1021/acs.orglett.0c01165.
Post, E.; Fletcher, S. Dissipative self-assembly, competition and inhibition in a self-reproducing protocell model. Chem. Sci. 2020, 11 (35), 9434–9442. DOI: 10.1039/d0sc02768e.
Myrgorodska, I.; Colomer, I.; Fletcher, S. Oligomerization Driven by Phase Separation. ChemSystemsChem 2020, 2 (5), 5. DOI: 10.1002/syst.201900059.
Lebedeva, M.; Palmieri, E.; Kukura, P.; Fletcher, S. Emergence and Rearrangement of Dynamic Supramolecular Aggregates Visualized by Interferometric Scattering Microscopy. ACS Nano 2020, 14 (9), 11160–11168. DOI: 10.1021/acsnano.0c02414.
Kucera, R.; Goetzke, F.; Fletcher, S. An Asymmetric Suzuki-Miyaura Approach to Prostaglandins: Synthesis of Tafluprost. Org. Lett. 2020, 22 (8), 2991–2994. DOI: 10.1021/acs.orglett.0c00745.
Karabiyikoglu, S.; Brethomé, A.; Palacin, T.; Paton, R.; Fletcher, S. Enantiomerically enriched tetrahydropyridine allyl chlorides. Chem. Sci. 2020, 11 (16), 4125–4130. DOI: 10.1039/d0sc00377h.
Engwerda, A.; Southworth, J.; Lebedeva, M.; Scanes, R.; Kukura, P.; Fletcher, S. Coupled Metabolic Cycles Allow Out-of-Equilibrium Autopoietic Vesicle Replication. Angew. Chem.-Int. Edit. 2020, 59 (46), 20361–20366. DOI: 10.1002/anie.202007302.
Engwerda, A.; Fletcher, S. A molecular assembler that produces polymers. Nat. Commun. 2020, 11 (1), 7. DOI: 10.1038/s41467-020-17814-0.
Colomer, I.; Borissov, A.; Fletcher, S. Selection from a pool of self-assembling lipid replicators. Nat. Commun. 2020, 11 (1), 9. DOI: 10.1038/s41467-019-13903-x.
Ardkhean, R.; Fletcher, S.; Paton, R. Ligand Design for Asymmetric Catalysis: Combining Mechanistic and Chemoinformatics Approaches. In New Directions in the Modeling of Organometallic Reactions, Lledos, A., Ujaque, G. Eds.; Topics in Organometallic Chemistry, Vol. 67; Springer International Publishing Ag, 2020; pp 153–189.
2019
Wang, J.; Palacin, T.; Fletcher, S. β-Chloroaldehydes from Trapping Zirconium Enolates Produced in Asymmetric 1,4-Additions. Org. Lett. 2019, 21 (2), 378–381. DOI: 10.1021/acs.orglett.8b03520.
Post, E.; Fletcher, S. Controlling the Kinetics of Self-Reproducing Micelles by Catalyst Compartmentalization in a Biphasic System. J. Org. Chem. 2019, 84 (5), 2741–2755. DOI: 10.1021/acs.joc.8b03149.
Morrow, S.; Colomer, I.; Fletcher, S. A chemically fuelled self-replicator. Nat. Commun. 2019, 10, 9. DOI: 10.1038/s41467-019-08885-9.
Jacques, R.; Hell, A.; Pullin, R.; Fletcher, S. Desymmetrization of meso-bisphosphates via rhodium catalyzed asymmetric allylic arylation. Tetrahedron 2019, 75 (42), 7. DOI: 10.1016/j.tet.2019.130560.
González, J.; van Dijk, L.; Goetzke, F.; Fletcher, S. Highly enantioselective rhodium-catalyzed cross-coupling of boronic acids and racemic allyl halides. Nat. Protoc. 2019, 14 (10), 2972–2985. DOI: 10.1038/s41596-019-0209-8.
González, J.; Schäfer, P.; Fletcher, S. Highly Enantioselective Hiyama Cross-Coupling via Rh-Catalyzed Allylic Arylation of Racemic Allyl Chlorides. Organometallics 2019, 38 (20), 3991–3995. DOI: 10.1021/acs.organomet.9b00197.
Goetzke, F.; Mortimore, M.; Fletcher, S. Enantio- and Diastereoselective Suzuki-Miyaura Coupling with Racemic Bicycles. Angew. Chem.-Int. Edit. 2019, 58 (35), 12128–12132. DOI: 10.1002/anie.201906478.
Brethomé, A.; Paton, R.; Fletcher, S. Retooling Asymmetric Conjugate Additions for Sterically Demanding Substrates with an Iterative Data-Driven Approach. ACS Catal. 2019, 9 (8), 7179–7187. DOI: 10.1021/acscatal.9b01814.
Brethomé, A.; Fletcher, S.; Paton, R. Conformational Effects on Physical-Organic Descriptors: The Case of Sterimol Steric Parameters. ACS Catal. 2019, 9 (3), 2313–2323. DOI: 10.1021/acscatal.8b04043.
2018
van Dijk, L.; Tilby, M.; Szpera, R.; Smith, O.; Bunce, H.; Fletcher, S. Molecular machines for catalysis. Nat. Rev. Chem. 2018, 2 (3), 18, Review. DOI: 10.1038/s41570-018-0117.
Schäfer, P.; Palacin, T.; Sidera, M.; Fletcher, S. Asymmetric Suzuki-Miyaura coupling of heterocycles via Rhodium-catalysed allylic arylation of racemates (vol 8, 15762, 2017). Nat. Commun. 2018, 9, 4, Correction. DOI: 10.1038/ncomms16216.
Post, E.; Bissette, A.; Fletcher, S. Self-reproducing micelles coupled to a secondary catalyst. Chem. Commun. 2018, 54 (63), 8777–8780. DOI: 10.1039/c8cc02136h.
Mistry, N.; Fletcher, S. Catalytic asymmetric synthesis of geminal-dicarboxylates. Chem. Sci. 2018, 9 (29), 6307–6312. DOI: 10.1039/c8sc01786g.
Gao, Z.; Fletcher, S. Construction of β to carbonyl stereogenic centres by asymmetric 1,4-addition of alkylzirconocenes to dienones and ynenones. Chem. Commun. 2018, 54 (29), 3601–3604. DOI: 10.1039/c8cc01201f.
Colomer, I.; Morrow, S.; Fletcher, S. A transient self-assembling self-replicator. Nat. Commun. 2018, 9, 6. DOI: 10.1038/s41467-018-04670-2.
Ardkhean, R.; Mortimore, M.; Paton, R.; Fletcher, S. Formation of quaternary centres by copper catalysed asymmetric conjugate addition to β-substituted cyclopentenones with the aid of a quantitative structure-selectivity relationship. Chem. Sci. 2018, 9 (9), 2628–2632. DOI: 10.1039/c7sc05304e.
2017
Schäfer, P.; Sidera, M.; Palacin, T.; Fletcher, S. Asymmetric cross-coupling of alkyl, alkenyl and (hetero)aryl nucleophiles with racemic allyl halides. Chem. Commun. 2017, 53 (93), 12499–12511. DOI: 10.1039/c7cc07151e.
Schäfer, P.; Palacin, T.; Sidera, M.; Fletcher, S. Asymmetric Suzuki-Miyaura coupling of heterocycles via Rhodium-catalysed allylic arylation of racemates. Nat. Commun. 2017, 8, 8. DOI: 10.1038/ncomms15762.
Rideau, E.; You, H.; Sidera, M.; Claridge, T.; Fletcher, S. Mechanistic Studies on a Cu-Catalyzed Asymmetric Allylic Alkylation with Cyclic Racemic Starting Materials. J. Am. Chem. Soc. 2017, 139 (15), 5614–5624. DOI: 10.1021/jacs.7b02440.
Morrow, S.; Bissette, A.; Fletcher, S. Potential for minimal self-replicating systems in a dynamic combinatorial library of equilibrating imines. Tetrahedron 2017, 73 (33), 5005–5010. DOI: 10.1016/j.tet.2017.06.045.
Morrow, S.; Bissette, A.; Fletcher, S. Transmission of chirality through space and across length scales. Nat. Nanotechnol. 2017, 12 (5), 410–419, Review. DOI: 10.1038/nnano.2017.62.
Gao, Z.; Fletcher, S. Acyclic quaternary centers from asymmetric conjugate addition of alkylzirconium reagents to linear trisubstituted enones. Chem. Sci. 2017, 8 (1), 641–646. DOI: 10.1039/c6sc02811j.
Gao, Z.; Fletcher, S. Asymmetric conjugate addition of alkylzirconium reagents to α,β-unsaturated thioesters: access to fragrances and acyclic stereochemical arrays. Chem. Commun. 2017, 53 (73), 10216–10219. DOI: 10.1039/c7cc05433e.
Asshoff, S.; Lancia, F.; Iamsaard, S.; Matt, B.; Kudernac, T.; Fletcher, S.; Katsonis, N. High-Power Actuation from Molecular Photoswitches in Enantiomerically Paired Soft Springs. Angew. Chem.-Int. Edit. 2017, 56 (12), 3261–3265. DOI: 10.1002/anie.201611325.
Ardkhean, R.; Roth, P.; Maksyrnowicz, R.; Curran, A.; Peng, Q.; Paton, R.; Fletcher, S. Enantioselective Conjugate Addition Catalyzed by a Copper Phosphoramidite Complex: Computational and Experimental Exploration of Asymmetric Induction. ACS Catal. 2017, 7 (10), 6729–6737. DOI: 10.1021/acscatal.7b01453.
2016
Ortega-Arroyo, J.; Bissette, A.; Kukura, P.; Fletcher, S. Visualization of the spontaneous emergence of a complex, dynamic, and autocatalytic system. Proc. Natl. Acad. Sci. U. S. A. 2016, 113 (40), 11122–11126. DOI: 10.1073/pnas.1602363113.
Mistry, N.; Fletcher, S. Phosphoramidite Ligands Based on Simple 1,2-Diols: Synthesis, Use in Copper-Catalyzed Asymmetric Additions, and Achirotopic Stereogenic Phosphorus Centres. Adv. Synth. Catal. 2016, 358 (15), 2489–2496. DOI: 10.1002/adsc.201600368.
MacDonald, J.; Sidera, M.; Fletcher, S.; Shaver, M. Living and immortal polymerization of seven and six membered lactones to high molecular weights with aluminum salen and salan catalysts. Eur. Polym. J. 2016, 74, 287–295. DOI: 10.1016/j.eurpolymj.2015.11.032.
Iamsaard, S.; Villemin, E.; Lancia, F.; Asshoff, S.; Fletcher, S.; Katsonis, N. Preparation of biomimetic photoresponsive polymer springs. Nat. Protoc. 2016, 11 (10), 1788–1797. DOI: 10.1038/nprot.2016.087.
Iamsaard, S.; Anger, E.; Asshoff, S.; Depauw, A.; Fletcher, S.; Katsonis, N. Fluorinated Azobenzenes for Shape-Persistent Liquid Crystal Polymer Networks. Angew. Chem.-Int. Edit. 2016, 55 (34), 9908–9912. DOI: 10.1002/anie.201603579.
Garrec, K.; Fletcher, S. Cp2ZrMeCl: A Reagent for Asymmetric Methyl Addition. Org. Lett. 2016, 18 (15), 3814–3817. DOI: 10.1021/acs.orglett.6b01829.
2015
You, H.; Rideau, E.; Sidera, M.; Fletcher, S. Non-stabilized nucleophiles in Cu-catalysed dynamic kinetic asymmetric allylic alkylation. Nature 2015, 517 (7534), 351–355. DOI: 10.1038/nature14089.
Sidera, M.; Fletcher, S. Cu-catalyzed asymmetric addition of sp2-hybridized zirconium nucleophiles to racemic allyl bromides. Chem. Commun. 2015, 51 (24), 5044–5047. DOI: 10.1039/c5cc00421g.
Sidera, M.; Fletcher, S. Rhodium-catalysed asymmetric allylic arylation of racemic halides with arylboronic acids. Nat. Chem. 2015, 7 (11), 935–939. DOI: 10.1038/nchem.2360.
Roth, P.; Fletcher, S. Enantioselective Copper(I)-Phosphoramidite Catalyzed Addition of Alkylzirconium Species to Acyclic Enones. Org. Lett. 2015, 17 (4), 912–915. DOI: 10.1021/acs.orglett.5b00021.
Rideau, E.; Mäsing, F.; Fletcher, S. Asymmetric Conjugate Addition of Alkylzirconocenes to Cyclopent-4-ene-1,3-dione Monoacetals. Synthesis 2015, 47 (15), 2217–2222. DOI: 10.1055/s-0034-1379928.
Rideau, E.; Fletcher, S. Copper-catalysed asymmetric allylic alkylation of alkylzirconocenes to racemic 3,6-dihydro-2H-pyrans. Beilstein J. Org. Chem. 2015, 11, 2435–2443. DOI: 10.3762/bjoc.11.264.
Mola, L.; Sidera, M.; Fletcher, S. Asymmetric Remote C-H Functionalization: Use of Internal Olefins in Tandem Hydrometallation-Isomerization-Asymmetric Conjugate Addition Sequences. Aust. J. Chem. 2015, 68 (3), 401–403. DOI: 10.1071/ch14556.
Maksymowicz, R.; Bissette, A.; Fletcher, S. Asymmetric Conjugate Additions and Allylic Alkylations Using Nucleophiles Generated by Hydro- or Carbometallation. Chem.-Eur. J. 2015, 21 (15), 5668–5678. DOI: 10.1002/chem.201405855.
Caprioglio, D.; Fletcher, S. An alternative synthesis of the breast cancer drug fulvestrant (Faslodex®): catalyst control over C-C bond formation. Chem. Commun. 2015, 51 (80), 14866–14868. DOI: 10.1039/c5cc05805h.
Bissette, A.; Fletcher, S. Novel applications of physical autocatalysis. Orig. Life Evol. Biosph. 2015, 45 (1-2), 21–30, ; Proceedings Paper. DOI: 10.1007/s11084-015-9404-y.
Bissette, A.; Fletcher, S. SYSTEMS CHEMISTRY Selecting complex behaviour. Nat. Chem. 2015, 7 (1), 15–17, News Item. DOI: 10.1038/nchem.2130.
Bassolino, G.; Sovdat, T.; Duarte, A.; Lim, J.; Schnedermann, C.; Liebel, M.; Odell, B.; Claridge, T.; Fletcher, S.; Kukura, P. Barrier less Photoisomerization of 11-cis Retinal Protonated Schiff Base in Solution. J. Am. Chem. Soc. 2015, 137 (39), 12434–12437. DOI: 10.1021/jacs.5b06492.
Anger, E.; Fletcher, S. Simple Azo Dyes Provide Access to Versatile Chiroptical Switches. Eur J Org Chem 2015, 2015 (17), 3651–3655. DOI: 10.1002/ejoc.201500485.
2014
Roth, P.; Sidera, M.; Maksymowicz, R.; Fletcher, S. Copper-catalyzed asymmetric conjugate addition of alkylzirconium reagents to cyclic enones to form quaternary centers. Nat. Protoc. 2014, 9 (1), 104–111. DOI: 10.1038/nprot.2013.169.
Matt, B.; Imsaard, S.; Asshoff, S.; Cornelissen, J.; Fletcher, S.; Katsonis, N. Conversion of light into macroscopic helical motion. Abstr. Pap. Am. Chem. Soc. 2014, 247, 1, Meeting Abstract.
Maciver, E.; Maksymowicz, R.; Wilkinson, N.; Roth, P.; Fletcher, S. Asymmetric Conjugate Addition of Alkylzirconium Reagents to α,β-Unsaturated Lactones. Org. Lett. 2014, 16 (12), 3288–3291. DOI: 10.1021/ol501292x.
Iamsaard, S.; Asshoff, S.; Matt, B.; Kudernac, T.; Cornelissen, J.; Fletcher, S.; Katsonis, N. Conversion of light into macroscopic helical motion. Nat. Chem. 2014, 6 (3), 229–235. DOI: 10.1038/nchem.1859.
Bissette, A.; Odell, B.; Fletcher, S. Physical autocatalysis driven by a bond-forming thiol-ene reaction. Nat. Commun. 2014, 5, 8. DOI: 10.1038/ncomms5607.
2013
Sidera, M.; Roth, P.; Maksymowicz, R.; Fletcher, S. Formation of Quaternary Centers by Copper-Catalyzed Asymmetric Conjugate Addition of Alkylzirconium Reagents. Angew. Chem.-Int. Edit. 2013, 52 (31), 7995–7999. DOI: 10.1002/anie.201303202.
Maksymowicz, R.; Sidera, M.; Roth, P.; Fletcher, S. A Convenient Catalytic Asymmetric Conjugate Addition Reaction to Enones Using Alkylzirconium Reagents. Synthesis 2013, 45 (19), 2662–2668. DOI: 10.1055/s-0033-1339485.
Maksymowicz, R.; Roth, P.; Thompson, A.; Fletcher, S. Hydrometallation-asymmetric conjugate addition: application to complex molecule synthesis. Chem. Commun. 2013, 49 (39), 4211–4213. DOI: 10.1039/c2cc37155c.
Bissette, A.; Fletcher, S. Mechanisms of Autocatalysis. Angew. Chem.-Int. Edit. 2013, 52 (49), 12800–12826, Review. DOI: 10.1002/anie.201303822.
2012
Sovdat, T.; Bassolino, G.; Liebel, M.; Schnedermann, C.; Fletcher, S.; Kukura, P. Backbone Modification of Retinal Induces Protein-like Excited State Dynamics in Solution. J. Am. Chem. Soc. 2012, 134 (20), 8318–8320. DOI: 10.1021/ja3007929.
Maksymowicz, R.; Roth, P.; Fletcher, S. Copper-catalysed asymmetric 1,4-conjugate addition of alkylzirconium compounds. Abstr. Pap. Am. Chem. Soc. 2012, 243, 1, Meeting Abstract.
Maksymowicz, R.; Roth, P.; Fletcher, S. Catalytic asymmetric carbon-carbon bond formation using alkenes as alkylmetal equivalents. Nat. Chem. 2012, 4 (8), 649–654. DOI: 10.1038/nchem.1394.
2011
Mao, B.; Geurts, K.; Fañanás-Mastral, M.; van Zijl, A.; Fletcher, S.; Minnaard, A.; Feringa, B. Catalytic Enantioselective Synthesis of Naturally Occurring Butenolides via Hetero-Allylic Alkylation and Ring Closing Metathesis. Org. Lett. 2011, 13 (5), 948–951. DOI: 10.1021/ol102994q.
Fletcher, S.; Solà, J.; Holt, D.; Brown, R.; Clayden, J. Synthesis of enantiomerically enriched (R)-13C-labelled 2-aminoisobutyric acid (Aib) by conformational memory in the alkylation of a derivative of L-alanine. Beilstein J. Org. Chem. 2011, 7, 1304–1309. DOI: 10.3762/bjoc.7.152.
Castellanos, A.; Fletcher, S. Current Methods for Asymmetric Halogenation of Olefins. Chem.-Eur. J. 2011, 17 (21), 5766–5776, Review. DOI: 10.1002/chem.201100105.
2002 - 2010
Solà, J.; Fletcher, S.; Castellanos, A.; Clayden, J. Nanometer-Range Communication of Stereochemical Information by Reversible Switching of Molecular Helicity. Angew. Chem.-Int. Edit. 2010, 49 (38), 6836–6839. DOI: 10.1002/anie.201001130.
Clayden, J.; Fletcher, S.; Senior, J.; Worrall, C. Hindered diarylether and diarylsulfone bisphosphine ligands: atropisomerism and palladium complexes. Tetrahedron-Asymmetry 2010, 21 (11-12), 1355–1360. DOI: 10.1016/j.tetasy.2010.06.017.
Fletcher, S. BUILDING BLOCKS OF LIFE Growing the seeds of homochirality. Nat. Chem. 2009, 1 (9), 692–693, News Item. DOI: 10.1038/nchem.455.
Clayden, J.; Fletcher, S.; Rowbottom, S.; Helliwell, M. Conformational Preferences of a Polar Biaryl: A Phase- and Enantiomeric Purity-Dependent Molecular Hinge. Org. Lett. 2009, 11 (11), 2313–2316. DOI: 10.1021/ol9006635.
Clayden, J.; Fletcher, S.; McDouall, J.; Rowbottom, S. Controlling Axial Conformation in 2-Arylpyridines and 1-Arylisoquinolines: Application to the Asymmetric Synthesis of QUINAP by Dynamic Thermodynamic Resolution. J. Am. Chem. Soc. 2009, 131 (14), 5331–5343. DOI: 10.1021/ja900722q.
Geurts, K.; Fletcher, S.; van Zijl, A.; Minnaard, A.; Feringa, B. Copper-catalyzed asymmetric allylic substitution reactions with organozinc and Grignard reagents. Pure Appl. Chem. 2008, 80 (5), 1025–1037, ; Proceedings Paper. DOI: 10.1351/pac200880051025. t
Clive, D.; Peng, J.; Fletcher, S.; Ziffle, V.; Wingert, D. Synthesis of diverse 2,3-dihydroindoles, 1,2,3,4-tetrahydroquinolines, and benzo-fused azepines by formal radical cyclization onto aromatic rings. J. Org. Chem. 2008, 73 (6), 2330–2344. DOI: 10.1021/jo7026307.
Foo, A.; Fletcher, S.; Langler, R.; Porter, C.; Branch, D. Structure-function studies for in vitro chemical inhibition of Fcγ receptor-mediated phagocytosis. Transfusion 2007, 47 (2), 290–298. DOI: 10.1111/j.1537-2995.2007.01105.x.
Fletcher, S.; Jagt, R.; Feringa, B. An astrophysically-relevant mechanism for amino acid enantiomer enrichment. Chem. Commun. 2007, (25), 2578–2580. DOI: 10.1039/b702882b.
Howell, G.; Fletcher, S.; Geurts, K.; ter Horst, B.; Feringa, B. Catalytic asymmetric synthesis of acyclic arrays by tandem 1,4-addition-aldol reactions. J. Am. Chem. Soc. 2006, 128 (46), 14977–14985. DOI: 10.1021/ja0651862.
Geurts, K.; Fletcher, S.; Feringa, B. Copper catalyzed asymmetric synthesis of chiral allylic esters. J. Am. Chem. Soc. 2006, 128 (49), 15572–15573. DOI: 10.1021/ja065780b.
Griffiths, R.; Wong, W.; Fletcher, S.; Penn, L.; Langler, R. Novel disulfides with antitumour efficacy and specificity. Aust. J. Chem. 2005, 58 (2), 128–136. DOI: 10.1071/ch03105.
Fletcher, S.; Dumur, F.; Pollard, M.; Feringa, B. A reversible, unidirectional molecular rotary motor driven by chemical energy. Science 2005, 310 (5745), 80–82. DOI: 10.1126/science.1117090.
Fletcher, S.; Clive, D.; Peng, J.; Wingert, D. Oxidation of p-aminophenols and formal radical cyclization onto benzene rings: Formation of benzo-fused nitrogen heterocycles. Org. Lett. 2005, 7 (1), 23–26. DOI: 10.1021/ol047977j.
Bewick, S.; Duffy, S.; Fletcher, S.; Langler, R.; Morrison, H.; O'Brien, E.; Ross, C.; Stephenson, V. The S2 oxygen atoms are essential for the pronounced fungitoxicity of the sulfur-rich natural product, dysoxysulfone. Aust. J. Chem. 2005, 58 (3), 218–223. DOI: 10.1071/ch03253.
Clive, D.; Fletcher, S.; Liu, D. Formal radical cyclization onto benzene rings: a general method and its use in the synthesis of ent-nocardione A. J. Org. Chem. 2004, 69 (10), 3282–3293. DOI: 10.1021/jo030364k.
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